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Madabhushi believes his expertise in DNA breaks in neurons could assistance illuminate the molecular mechanisms resulting in gene fusions in prostate cancer.
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Gene fusions crop up when DNA breaks arise at the same time in different aspects of the genome and so are repaired improperly, making sure that elements of the genome that do not belong alongside one another turn into fused. In prostate most cancers, these fusions generally type involving the same sets of genes.
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it could appear to be odd that a researcher in the Office of Psychiatry is working on prostate cancer. But being a postdoctoral researcher in neuroscience, Madabhushi located that when neurons are stimulated, as in reaction to new sensory encounters, In addition they incur DNA breaks at precise areas inside of their genomes.
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But there is no treatment method for so-called “castration-resistant” prostate most cancers, which isn't going to reply to testosterone depletion and will keep on to develop.
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